Bonicel™

Bonicel™ is the first science-backed, probiotic-derived personal care ingredient. It has been shown in four clinical studies to increase skin hydration and elasticity and reduce the appearance of fine lines, wrinkles, roughness, pore size and redness. Bonicel is the trademarked name for the metabolic byproduct produced during the bacterial fermentation process of Bacillus coagulans that contains the optimal combination of naturally derived metabolites.
What is a probiotic? According the FAO/WHO, a probiotic is defined as: Live microorganisms which when administered in adequate amounts confer a health benefit on the host.
Is Bonicel a probiotic?  Bonicel is a probiotic-derived ingredient. It is derived from the an optimized form of  Bacillus coagulans's fermentation broth. Although a probiotic organism produces Bonicel, Bonicel is not a probiotic. We do not use live bacteria in our products.

How is Bonicel produced?
Bacillus ferment is produced through a proprietary *fermentation process of the bacteria Bacillus coagulans. We use the metabolic byproduct produced during the bacterial fermentation process of Bacillus coagulan, which includes maximum amounts of:
  • Naturally derived L+ Lactic acid
  • Bacteriocins
  • Enzymes
  • Other metabolites 

*Fermentation is an energy-releasing process of certain microorganisms that takes place in the absence of oxygen. These microorganisms perform fermentation to obtain the energy they need to carry on their life processes.

The specific byproduct resulting from fermentation is determined by the type of microorganism carrying on the process and the substance in which the fermentation occurs. For example, wine is the product of yeast fermentation in fruit juice.

What does Bonicel do?

  • Reduces skin inflammation
  • Improves skin elasticity
  • Improves skin moisturization
  • Reduces the appearance of fine lines & wrinkles
  • Reduces the appearance of roughness
  • Reduces pore size
  • Reduces the appearance of redness
  • Reduces under eye puffiness 


Is Bonicel backed by research?

Yes. Bonicel has been studied in a number of human clinical trials which
Provides proof to the scientific community that Bonicel is safe and effective.

The Science Behind Bonicel
Ganeden Biotech is a science-driven organization that invests millions of dollars into ongoing research. Ganeden brings probiotic and probiotic-derived products to market only when they demonstrate safety and efficacy, providing consumers with actual benefits – not just marketing hype.

Facial Lotion Clinical Pilot Study
Ganeden Biotech performed an 8 week study to evaluate and compare the effectiveness of a topical anti-aging product containing Bacillus ferment (Bonicel) versus placebo to improve skin hydration & moisturization, improve skin elasticity, reduce the appearance of fine lines & wrinkles around the eye area, decrease the appearance of under-eye puffiness and decrease the appearance of dark circles.

The test group consisted of female subjects in the age range of 35-60 years with at least 25% having under eye puffiness and 25% having dark circles.

The inclusion of Bonicel was found to:

  • Decrease the number of coarse skin lines by 20.57%
  • Show a 17% increase in the number of subjects showing improvement of eye area fine lines & wrinkles.
  • Show a 8.33% increase in the number of subjects showing improvement of under eye puffiness
  • Increase skin hydration by 7.13%
  • Decrease skin shadows by 7.09%
  • Increase skin smoothness by 4.33%
  • Increase skin elasticity by 3.11% 

Facial Lotion Clinical Confirmation Study
Ganeden Biotech performed a 28 day study to confirm the findings of previous studies that demonstrated the multiple benefits to using a cream with Bonicel.

The study was randomized, double-blind and placebo controlled on female subjects in the age range of 35-60 with mild to moderate fines lines & wrinkles. Subjects were not using anti-aging products, nor had used them within 30 days of the start of the trial.

The subjects using the product containing Bonicel experienced:

  • Decreases in the appearance of fine lines & wrinkles of 62.9%
  • Decreases in the appearance of pore size of 48.1%
  • Decreases in the appearance of redness of 33.3%
  • Reductions in roughness of 19.4%
  • Increases in moisturization of 19.1%
  • Increases in elasticity of 5.2%



Reduction in the appearance of fine lines & wrinkles


Reduction in the appearance of pore sizel

In a 4-week clinical trial, wrinkle assessment was conducted using the advanced Visioscan image analysis system.The Visioscan takes a direct image of the skin using a measuring head containing a CCD-camera. In the images above, dark pixels represent lines and wrinkles. These powerful images demonstrate the 63% improvement in the appearance of wrinkles experienced by study participants.